let-7 Contributes to Diabetic Retinopathy but Represses Pathological Ocular Angiogenesis
نویسندگان
چکیده
منابع مشابه
Let-7 contributes to diabetic retinopathy but represses pathological ocular angiogenesis.
The in vivo function of microRNAs (miRNAs or miRs) in diabetic retinopathy (DR) and age-related macular degeneration (AMD) remains unclear. Here we report that let-7 family members are expressed in retinal and choroidal endothelial cells (EC). In ECs, overexpression of let-7 by adenovirus represses EC proliferation, migration, and networking in vitro, while inhibition of the let-7 family with a...
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Diabetic retinopathy continues to be an important cause of adult blindness among Americans and Brazilians. There are determinant environmental factors in the development of diabetic retinopathy although increasing evidence suggests a genetic component in diabetic retinopathy. The advances made during the last two decades with the purpose of improving the understanding of the mechanisms involved...
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PURPOSE The apoptosis of human umbilical vein endothelial cells has been reportedly induced by the protein transthyretin (TTR). In human ocular tissue, TTR is generally considered to be secreted mainly by retinal pigment epithelial cells (hRPECs); however, whether TTR affects the development of neovascularization in diabetic retinopathy (DR) remains unclear. METHODS Natural and simulated DR m...
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Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of blindness in the working-age population. Impaired blood-retinal barrier function leads to macular edema that is closely associated with the deterioration of central vision. We previously demonstrated that the neuronal guidance cue netrin-1 activates a program of reparative angiogenesis in microglia within the i...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2017
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00001-17